Image-derived, three-dimensional generative models of cellular organization
نویسندگان
چکیده
منابع مشابه
Image-derived, three-dimensional generative models of cellular organization.
Given the importance of subcellular location to protein function, computational simulations of cell behaviors will ultimately require the ability to model the distributions of proteins within organelles and other structures. Toward this end, statistical learning methods have previously been used to build models of sets of two-dimensional microscope images, where each set contains multiple image...
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To my family and friends for the good times, laughs and support v Abstract Understanding cellular organization is a major goal of systems biology. Cellular organization affects the behavior of cells and many diseases and disorders impact the spatial organization of cells and their morphologies in turn. There are many current means of studying these systems and their effects. High-content imagin...
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15 صفحه اولCellOrganizer: Image-derived models of subcellular organization and protein distribution.
This chapter describes approaches for learning models of subcellular organization from images. The primary utility of these models is expected to be from incorporation into complex simulations of cell behaviors. Most current cell simulations do not consider spatial organization of proteins at all, or treat each organelle type as a single, idealized compartment. The ability to build generative m...
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ژورنال
عنوان ژورنال: Cytometry Part A
سال: 2011
ISSN: 1552-4922
DOI: 10.1002/cyto.a.21066